Bevirimat

SIGMA/SML2057 - ≥98% (HPLC)

Synonym: (3b)-3-(3-Carboxy-3-methyl-1-oxobutoxy)lup-20(29)-en-28-oic acid; 3-0-(3′-3′-Dimethylsuccinyl)betulinic acid; BVM; MPC-4326; O-(3,3-Dimethylsuccinyl)betulinic acid; PA-457

CAS Number: 174022-42-5
Empirical Formula (Hill Notation): C₃₆H₅₆O₆
Molecular Weight: 584.83
MDL Number: MFCD00954243
Linear Formula: C₃₆H₅₆O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2057-5MG	5 mg	$145.00 1/EA	Add To Favorites
45-SML2057-25MG	25 mg	$584.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C36H56O6/c1-21(2)22-12-17-36(30(40)41)19-18-34(8)23(28(22)36)10-11-25-33(7)15-14-26(42-27(37)20-31(3,4)29(38)39)32(5,6)24(33)13-16-35(25,34)9/h22-26,28H,1,10-20H2,2-9H3,(H,38,39)(H,40,41)/t22-,23+,24-,25+,26-,28+,33-,34+,35+,36-/m0/s1
InChI key	YJEJKUQEXFSVCJ-WRFMNRASSA-N
SMILES string	CC([C@H]1[C@]2([H])[C@@]3([H])CC[C@@]4([H])[C@](CC[C@]5([H])[C@]4(C)CC[C@H](OC(CC(C)(C(O)=O)C)=O)C5(C)C)(C)[C@]3(C)CC[C@@]2(C(O)=O)CC1)=C
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Bevirimat is the first in class HIV maturation inhibitor. It acts by inhibiting the processing of the Gag capsid (CA)/spacer peptide 1 (SP1), which causes accumulation of CA/SP1 (p25) precursor proteins and blocks maturation of the viral core particle.
Biochem/physiol Actions:	Inhibitor of HIV-1 maturation
Biochem/physiol Actions:	It also causes defective core condensation and releases the non-infectious virus particles from cells infected with human immunodeficiency virus (HIV). Thus, bevirimat blocks the spread of HIV infection to other cells.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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