LBQ657

SIGMA/SML2064 - ≥97% (HPLC)

Synonym: (2R,4S)-5-(Biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid; Desethyl sacubitril; Sacubitrilat

Empirical Formula (Hill Notation): C₂₂H₂₅NO₅
Molecular Weight: 383.44
MDL Number: MFCD00921225
Linear Formula: C₂₂H₂₅NO₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2064-5MG	5 mg	$131.00 1/EA	Add To Favorites
45-SML2064-25MG	25 mg	$530.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to beige
form	powder
InChI	1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
InChI key	DOBNVUFHFMVMDB-BEFAXECRSA-N
optical activity	[α]/D -35 to -27°, c = 1 in methanol
shipped in	wet ice
SMILES string	OC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H336 - H372
Precautionary statements	P314
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

To Order From a Quote