FX1
SIGMA/SML2074 - ≥98% (HPLC)
Synonym: (5Z)
Empirical Formula (Hill Notation): C14H9ClN2O4S2
Molecular Weight: 368.82
Linear Formula: C14H9ClN2O4S2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | red-brown |
form | powder |
storage temp. | 2-8°C |
Biochem/physiol Actions: | FX1 is a BCL6 inhibitor that effectively blocks BCL6 N-terminal BTB domain-mediated corepressors chromosome recruitment (by 61-87%/SMRT and 67-82%/BCOR; 50 μM FX1 for 30 min) and selectively suppresses BCL6-depenent growth (GI50 16-54 μM; >125 μM against BCL6-independent cells) in diffuse large B cell lymphoma (DLBCL) cultures, exhibiting greater affinity than its structure analog 79-6 or BCL6 corepressor SMRT for BTB domain (KD = 7 μM/FX1, 30 μM/SMRT, 129 μM/79-6). FX1 shows greater efficacy than 79-6 in reversing BCL6/corepressors-mediate |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |