Gimeracil

SIGMA/SML2075 - ≥98% (HPLC)

Synonym: 5-Chloropyridine-2,4-diol; 5-chloro-4-hydroxypyridin-2(1H)-one; CDHP; Gimestat

CAS Number: 103766-25-2
Empirical Formula (Hill Notation): C₅H₄ClNO₂
Molecular Weight: 145.54
MDL Number: MFCD08458352
Linear Formula: C₅H₄ClNO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2075-5MG	5 mg	$60.80 1/EA	Add To Favorites
45-SML2075-25MG	25 mg	$149.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to brown
form	powder
InChI	1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
InChI key	ZPLQIPFOCGIIHV-UHFFFAOYSA-N
SMILES string	Clc1c[nH][c](cc1O)=O
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:

Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine and the chemotherapeutic drug 5-fluorouracil (5FU). Gimeracil is shown to exhibit cancer-radiosensitizing efficacy in cultures in vitro (1 mM) and in mice in vivo (2.5-25 mg/kg, p.o.) in a DPYD-dependent manner via partial suppression of DNA repair by homologous recombination (HR).

Biochem/physiol Actions:

Orally active dihydropyrimidine dehydrogenase (DPYD) inhibitor with cancer-radiosensitizing efficacy in vitro and in vivo.

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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