Gimeracil
SIGMA/SML2075 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 103766-25-2
Empirical Formula (Hill Notation): C5H4ClNO2
Molecular Weight: 145.54
MDL Number: MFCD08458352
Linear Formula: C5H4ClNO2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to brown |
form | powder |
InChI | 1S/C5H4ClNO2/c6-3-2-7-5(9 |
InChI key | ZPLQIPFOCGIIHV-UHFFFAOYSA |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | Gimeracil (5-chloro-2, 4-dihydroxypyridine) is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine and the chemotherapeutic drug 5-fluorouracil (5FU). Gimeracil is shown to exhibit cancer-radiosensitizing efficacy in cultures in vitro (1 mM) and in mice in vivo (2.5-25 mg/kg, p.o.) in a DPYD-dependent manner via partial suppression of DNA repair by homologous recombination (HR). |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |