ATN-161

SIGMA/SML2079 - ≥98% (HPLC)

Synonym: 1-Acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-aspartamide; Ac-PHSCN-NH2; Ac-Pro-His-Ser-Cys-Asn-NH2, PHSCN (Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)

CAS Number: 262438-43-7
Empirical Formula (Hill Notation): C₂₃H₃₅N₉O₈S
Molecular Weight: 597.64
Linear Formula: C₂₃H₃₅N₉O₈S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2079-5MG	5 mg	$145.00 1/EA	Add To Favorites
45-SML2079-25MG	25 mg	$584.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C23H35N9O8S/c1-11(34)32-4-2-3-17(32)23(40)29-14(5-12-7-26-10-27-12)20(37)30-15(8-33)21(38)31-16(9-41)22(39)28-13(19(25)36)6-18(24)35/h7,10,13-17,33,41H,2-6,8-9H2,1H3,(H2,24,35)(H2,25,36)(H,26,27)(H,28,39)(H,29,40)(H,30,37)(H,31,38)/t13-,14-,15-,16-,17-/m0/s1
InChI key	MMHDBUJXLOFTLC-WOYTXXSLSA-N
shipped in	wet ice
SMILES string	SC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(CCC2)C(=O)C)Cc1nc[nH]c1)CO)C(=O)N[C@@H](CC(=O)N)C(=O)N
storage temp.	−20°C

Application:	ATN-161 has been used as an inhibitor of integrin α5β1 and αvβ3 in cultured platelet endothelial cell adhesion molecule (PECAM1)-positive endothelial cells isolated from AL (CECAL).
Biochem/physiol Actions:	Antagonist of integrin α5β1 receptor
Biochem/physiol Actions:	ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 was shown to have antiangigenic and antitumor activity.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12171501

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