Synonym: 1-Acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-aspartamide; Ac-PHSCN-NH2; Ac-Pro-His-Ser-Cys-Asn-NH2, PHSCN (Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)
CAS Number: 262438-43-7
Empirical Formula (Hill Notation): C23H35N9O8S
Molecular Weight: 597.64
Linear Formula: C23H35N9O8S
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C23H35N9O8S/c1-11(34)32-4-2-3-17(32)23(40)29-14(5-12-7-26-10-27-12)20(37)30-15(8-33)21(38)31-16(9-41)22(39)28-13(19(25)36)6-18(24)35/h7,10,13-17,33,41H,2-6,8-9H2,1H3,(H2,24,35)(H2,25,36)(H,26,27)(H,28,39)(H,29,40)(H,30,37)(H,31,38)/t13-,14-,15-,16-,17-/m0/s1 |
| InChI key |
MMHDBUJXLOFTLC-WOYTXXSLSA-N |
| shipped in |
wet ice |
| storage temp. |
−20°C |
| Application: |
ATN-161 has been used as an inhibitor of integrin α5β1 and αvβ3 in cultured platelet endothelial cell adhesion molecule (PECAM1)-positive endothelial cells isolated from AL (CECAL). |
| Biochem/physiol Actions: |
ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 was shown to have antiangigenic and antitumor activity. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
