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ATN-161

SIGMA/SML2079 - ≥98% (HPLC)

Synonym: 1-Acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-aspartamide; Ac-PHSCN-NH2; Ac-Pro-His-Ser-Cys-Asn-NH2, PHSCN (Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)

CAS Number: 262438-43-7
Empirical Formula (Hill Notation): C23H35N9O8S
Molecular Weight: 597.64
Linear Formula: C23H35N9O8S
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML2079-5MG 5 mg
$131.00
1/EA
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45-SML2079-25MG 25 mg
$530.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C23H35N9O8S/c1-11(34)32-4-2-3-17(32)23(40)29-14(5-12-7-26-10-27-12)20(37)30-15(8-33)21(38)31-16(9-41)22(39)28-13(19(25)36)6-18(24)35/h7,10,13-17,33,41H,2-6,8-9H2,1H3,(H2,24,35)(H2,25,36)(H,26,27)(H,28,39)(H,29,40)(H,30,37)(H,31,38)/t13-,14-,15-,16-,17-/m0/s1
InChI key MMHDBUJXLOFTLC-WOYTXXSLSA-N
shipped in wet ice
storage temp. −20°C
Application: ATN-161 has been used as an inhibitor of integrin α5β1 and αvβ3 in cultured platelet endothelial cell adhesion molecule (PECAM1)-positive endothelial cells isolated from AL (CECAL).
Biochem/physiol Actions: ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 was shown to have antiangigenic and antitumor activity.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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