Lys05

SIGMA/SML2097 - ≥98% (HPLC)

Synonym: Lys-01 3HCl; Lys-05; Lys01 3HCl; N-(7-Chloroquinolin-4-yl)-N′-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N′-methylethane-1,2-diamine trihydrochloride; N1-(7-Chloroquinolin-4-yl)-N2-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N2-methylethane-1,2-diamine trihydrochloride; PS-1001; PS1001

CAS Number: 1391426-24-6
Empirical Formula (Hill Notation): C₂₃H₂₃Cl₂N₅ · 3HCl
Molecular Weight: 549.75
Linear Formula: C₂₃H₂₃Cl₂N₅ · 3HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2097-5MG	5 mg	$121.00 1/EA	Add To Favorites
45-SML2097-25MG	25 mg	$467.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	JTUYDBHQGOZPQQ-UHFFFAOYSA-N
SMILES string	[Cl-].[Cl-].[Cl-].Clc1cc2nccc(c2cc1)[N+H2]CC[N+H](CC[N+H2]c3c4c(ncc3)cc(cc4)Cl)C
solubility	DMSO: 2 mg/mL, clear
storage condition	desiccated
storage temp.	−20°C

Application:	Lys05 has been used as an autophagy inhibitor to study its interactions with piperazine. It has also been used as a lysosomal inhibitor to study its effects on myogenesis in Gallus gallus.
Biochem/physiol Actions:	Dimeric chloroquine (CQ) with higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ both in vitro and in vivo.
Biochem/physiol Actions:	Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15.4 post 4 hr 10 μM treatment in LN229 glioblastoma cells vs. <6.4 with 100 μM CQ or HCQ). Lys05 also shows higher anticancer activity both in vitro (IC50 3.6-6.0 μM vs. 15.6-23.8 μM with HCQ in 1205Lu, c8161, LN229, HT-29 cultures) and in mice in vivo (EC50 in reducing tumor growth rate ∼10 mg/kg/day i.p.; HT29 xenografts) with toxicity observed only at high doses (≥80 mg/kg) as a result of significant lysozyme reduction.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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