RIPA-56
SIGMA/SML2100 - ≥98% (HPLC)
Synonym: N-
CAS Number: 1956370-21-0
Empirical Formula (Hill Notation): C13H19NO2
Molecular Weight: 221.30
Linear Formula: C13H19NO2
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C13H19NO2/c1-4-13(2,3) |
| InChI key | AVYVHIKSFXVDBG-UHFFFAOYSA |
| SMILES string | N(O)(Cc1ccccc1)C(=O)C(CC) |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Highly potent and selective receptor interacting protein 1 kinase (RIP1; RIPK1) type III inhibitor with in vitro and in vivo efficacy against necroptosis. |
| Biochem/physiol Actions: | RIPA-56 is a metabolically stable type III kinase inhibitor that targets receptor-interacting protein 1 kinase (RIP1; RIPK1) in a highly potent and selective manner (RIP1 IC50 = 13 nM) by locking RIP1 in its inactive form, exhibiting no inhibitory potency toward RIP3, IDO or a panel of multiple kinases (tested at 10, 200, and 5 μM, respectively). RIPA-56 protects against TNFα-induced necroptosis (necrosis) upon apoptosis/NF-κB pathway blockage (EC50 = 27 nM/murine L929 and 28 nM/human HT-29 cells) in cultures as well as TNFα-induced mortality and multiorgan damage in a murine model of systemic inflammatory response syndrome (SIRS) in vivo (100% survival rate with 3 mg/kg/12 h or single 6 mg/kg i.p.) with good pharmacokinetics and bioavailability (F post 10 mg/kg p.o. or i.p. dosing = 22% and 100%, respectively, of 2 mg/kg i.v.). Long-term daily RIPA-56 supplementation (150 or 300 mg/kg in chow) is reported to prevent aging-associated deterioration of the male reproductive system in mice. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |