GSK256066
SIGMA/SML2102
Synonym: 6-
CAS Number: 801312-28-7
Empirical Formula (Hill Notation): C27H26N4O5S
Molecular Weight: 518.58
MDL Number: MFCD18206923
Linear Formula: C27H26N4O5S
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | GSK256066 is a reversible and cAMP-competitive phosphodiesterase 4 (PDE4) inhibitor that targets all PDE4 subtypes with high affinity (IC50 = 53.7 pM against 2 nM [3H]-rolipram for binding HRBS in rat brain cytosol), potency and selectivity (pIC50 ≥11.31/11.5/11.42/11.94 against PDE4A/B/C/D vs. pIC50 = 5.73/5.92/5.93/5.39/5.28/ |
WGK Germany | WGK 3 |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |