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Ambrisentan

SIGMA/SML2104 - ≥98% (HPLC)

Synonym: (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid

CAS Number: 177036-94-1
Empirical Formula (Hill Notation): C22H22N2O4
Molecular Weight: 378.42
MDL Number: MFCD08672619
Linear Formula: C22H22N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2104-10MG 10 mg
 $145.00
1/EA		 Add To Favorites
45-SML2104-50MG 50 mg
 $584.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
InChI key OUJTZYPIHDYQMC-UHFFFAOYSA-N
optical activity [α]/D +160 to +190°, c = 0.5 in methanol
SMILES string CC1=CC(C)=NC(O[C@@H](C(C2=CC=CC=C2)(OC)C3=CC=CC=C3)C(O)=O)=N1
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Ambrisentan is an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It is 200-fold selective for the the ETA receptor subtype with a Ki of 1 nM for ETA and a Ki of 195 nM for ETB.
Biochem/physiol Actions: Endothelin ETA Receptor Antagonist; Antihypertensive; Pulmonary Hypertension Treatment
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H360FD
Precautionary statements P201 - P308 + P313
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41121706

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