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Roflupram

SIGMA/SML2106 - ≥98% (HPLC)

Synonym: 1-[4-(Difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-1-butanone; FFPM; ZL-n-91

CAS Number: 1093412-18-0
Empirical Formula (Hill Notation): C16H20F2O4
Molecular Weight: 314.32
Linear Formula: C16H20F2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2106-5MG 5 mg
 $98.40
1/EA		 Add To Favorites
45-SML2106-25MG 25 mg
 $397.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color colorless to light brown
form oil
InChI key IXURVUHDDXFYDR-UHFFFAOYSA-N
SMILES string O=C(CC(C)C)C1=CC=C(OC(F)F)C(OC2CCOC2)=C1
storage temp. 2-8°C
Biochem/physiol Actions: Anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor
Biochem/physiol Actions: Roflupram (FFPM) is a potent anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor that was found to suppress inflammasome activation in microglial cells by enhancing autophagy. In microglial BV-2 cells roflupram enhanced the level of microtubule-associated protein 1 light chain 3 II (LC3-II) and decreased the autophagy receptor ubiquitin-binding protein p62 (SQSTM1), enhancing autophagy, reducing the activation of inflammasome and suppressing the production of IL-1β. Roflupram (FFPM) was found to reverse learning and memory deficits in APP/PS1 transgenic mice.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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