Roflupram
SIGMA/SML2106 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 1093412-18-0
Empirical Formula (Hill Notation): C16H20F2O4
Molecular Weight: 314.32
Linear Formula: C16H20F2O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | colorless to light brown |
form | oil |
SMILES string | O=C(CC(C)C)C1=CC=C(OC(F)F |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Roflupram (FFPM) is a potent anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor that was found to suppress inflammasome activation in microglial cells by enhancing autophagy. In microglial BV-2 cells roflupram enhanced the level of microtubule-associated protein 1 light chain 3 II (LC3-II) and decreased the autophagy receptor ubiquitin-binding protein p62 (SQSTM1), enhancing autophagy, reducing the activation of inflammasome and suppressing the production of IL-1β. Roflupram (FFPM) was found to reverse learning and memory deficits in APP/PS1 transgenic mice. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |