ST034307
SIGMA/SML2109 - ≥98% (HPLC)
Synonym: 6-
CAS Number: 133406-29-8
Empirical Formula (Hill Notation): C10H4Cl4O2
Molecular Weight: 297.95
MDL Number: MFCD00760793
Linear Formula: C10H4Cl4O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | faint green to dark gray |
form | powder |
SMILES string | ClC(Cl)(Cl)C1=CC(C2=CC(Cl |
solubility | DMSO: 2 mg/mL, clear (warmed) |
storage temp. | −20°C |
Biochem/physiol Actions: | ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |