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HA15

SIGMA/SML2118 - ≥98% (HPLC)

Synonym: N-[4-[3-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-thiazolyl]-acetamide

CAS Number: 1609402-14-3
Empirical Formula (Hill Notation): C23H22N4O3S2
Molecular Weight: 466.58
MDL Number: MFCD30377202
Linear Formula: C23H22N4O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2118-5MG 5 mg
 $116.00
1/EA		 Add To Favorites
45-SML2118-25MG 25 mg
 $467.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C23H22N4O3S2/c1-15(28)24-23-25-20(14-31-23)16-7-4-8-17(13-16)26-32(29,30)22-12-6-9-18-19(22)10-5-11-21(18)27(2)3/h4-14,26H,1-3H3,(H,24,25,28)
InChI key LBSMEKVVMYSTIH-UHFFFAOYSA-N
SMILES string CC(NC1=NC(C2=CC=CC(NS(C3=C(C=CC=C4N(C)C)C4=CC=C3)(=O)=O)=C2)=CS1)=O
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: HA15 is a selective ligand of BiP/GRP78/HSPA5 chaperone that increases ER stress, leading to autophagic and apoptotic cell death in varies cancer cell lines including melanoma cells. HA15 inhibits inhibit the ATPase activity of BiP. HA15 inhibits tumor development in mice injected with A375 melanoma cells.
Biochem/physiol Actions: selective ligand of BiP/GRP78/HSPA5 chaperone that increases ER stress, leading to autophagic and apoptotic cell death in varies cancer cell lines
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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