Synonym: (1R,3S)-1-(3-((4-(2-Cyanophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Empirical Formula (Hill Notation): C31H31N5O3
Molecular Weight: 521.61
MDL Number: MFCD30742938
Linear Formula: C31H31N5O3
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
solubility |
DMSO: 2 mg/mL, clear |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Ned-K is a specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca2+ oscillations via two-pore channels (TPC1) and opening of the mitochondrial permeability transition pore (mPTP) in cardiomyocytes during simulated ischaemia and reperfusion. Ned-K protected cardiomyocytes from cell death during ischaemia and reperfusion injury in rats. |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |