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HPN-07

SIGMA/SML2163 - ≥98% (HPLC)

Synonym: 2, 4-Disulfonyl PBN; 2,4-Disulfophenyl-N-tert-butylnitrone; ARL 16556; CPI 22; Cerovive; Disodium 4-[(tert-butyl-imino) methyl]benzene-13-disulfonate N-oxide; Disufenton sodium; NXY-059; Nxy 059; OKN-007; OKN007; Oklahoma nitrone-007

CAS Number: 168021-79-2
Empirical Formula (Hill Notation): C11H13NO7S2 · 2Na
Molecular Weight: 381.33
MDL Number: MFCD09833648
Linear Formula: C11H13NO7S2 · 2Na
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2163-5MG 5 mg
 $71.50
1/EA		 Add To Favorites
45-SML2163-25MG 25 mg
 $291.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML2163-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C11H15NO7S2.2Na/c1-11(2,3)12(13)7-8-4-5-9(20(14,15)16)6-10(8)21(17,18)19;;/h4-7H,1-3H3,(H,14,15,16)(H,17,18,19);;/q;2*+1/p-2
InChI key XLZOVRYBVCMCGL-UHFFFAOYSA-L
SMILES string [O-]/[N+](C(C)(C)C)=CC(C=CC(S([O-])(=O)=O)=C1)=C1S([O-])(=O)=O.[Na+].[Na+]
solubility H2O: 2 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: Orally available NO-mimicking free radical trapping agent and sulfatase 2 (SULF2) inhibitor with in vivo efficacy in animal models of glioma and stroke.
Biochem/physiol Actions: Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water).
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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