(S)-(+)-Dimethindene maleate
SIGMA/SML2165 - ≥98% (HPLC)
Synonym: Dimetindene maleate; N,N-
CAS Number: 136152-65-3
Empirical Formula (Hill Notation): C20H24N2 · C4H4O4
Molecular Weight: 408.49
MDL Number: MFCD03701358
Linear Formula: C20H24N2 · C4H4O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
SMILES string | CN(C)CCC1=C([C@@H](C2=NC= |
solubility | H2O: 2 mg/mL, clear |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | (S)-(+)-Dimethindene maleate is an antagonist of muscarinic M2 and histamine H1 receptors, recently used as part of part of four-component chemical cocktail shown to convert pluripotent stem cells (PSCs) into extended pluripotent stem (EPS). (S)-(+)-Dimethindene is up to 40-fold more potent than the (R)-(-) enantiomer, with pKi values of 7.78 for M2, and lower affinities for M1, M3 and M4 (7.08, 6.7 and 7.0, respectively). (S)-(+)-Dimethindene has lower affinity for H1 than (R)-(-)- Dimethindene, with pA2 values of 7.48 vs. 9.42, respectively. |
Biochem/physiol Actions: | M2 and H1 antagonist, part of four-component chemical cocktail shown to convert pluripotent stem cells (PSCs) into extended pluripotent stem (EPS) |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |