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S 38093-2

SIGMA/SML2177 - ≥98% (HPLC)

Synonym: 4-(3-((3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride; S 38093; S-38093; S38093

CAS Number: 1403835-46-0
Empirical Formula (Hill Notation): C17H24N2O2 · HCl
Molecular Weight: 324.85
Linear Formula: C17H24N2O2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2177-5MG 5 mg
 $81.30
1/EA		 Add To Favorites
45-SML2177-25MG 25 mg
 $329.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
SMILES string [H][C@@]([C@]1([H])C2)(CCC1)CN2CCCOC3=CC=C(C(N)=O)C=C3.Cl
solubility H2O: 2 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: S 38093 is an orally available compound with selective affinity toward histamine H3 receptor (human/mouse/rat H3R Ki = 0.2/1.44/8.8 μM), but not other histaminergic receptors, exhbiting both antagonist (KB = 652 nM against 300 nM (R)-α-Methylhistamine-induced GTPγS recruitment to mH3 CHO membrane; KB = 110 nM against 1 μM histamine-induced cAMP downregulation in hH3 CHO cells) and inverse agonist activity (hH3/rH3 HEK basal cAMP enhancing EC50 = 1.7/9 μM; 48% inhibition of ionomycin-induced hH3 or rH3 HEK AA reslease by 10 μM S 38093). S 38093 is reported to improve AD- and age-associated memory and cognition deficits in mice (0.1-3 mg/kg/day p.o.) and rats (0.1-10 mg/kg p.o. or i;p.), as well as display antiallodynic and antihyperalgesic efficacy in rat models of neuropathic pain in vivo.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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