SA4503
SIGMA/SML2181 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 165377-44-6
Empirical Formula (Hill Notation): C23H32N2O2 · 2HCl
Molecular Weight: 441.43
MDL Number: MFCD09842336
Linear Formula: C23H32N2O2 · 2HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
SMILES string | COC1=CC=C(CCN2CCN(CCCC3=C |
solubility | H2O: 2 mg/mL, clear |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | SA4503 is a high affinity, orally active non-opioid intracellular receptor sigma-1 (σ1R) selective agonist (IC50 = 17.4 nM against 200 nM (+)-pentazocine for binding σ1R), exhibiting ~100-fold less affinity for the sigma 2 receptor subtype (σ2R) and little or no affinity toward 36 other receptors, ion channels and second messenger systems. Oral administration is reported to elicit cerebral acetylcholine (ACh) release in rat frontal cortex and hippocampus (5-20 mg/kg p.o.) and reduce immobility time in a mouse forced swimming test (Immobility time = 214.8 s without vs. 111.6 s with 1.0 mg/kg oral dosage). |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |