Poloppin
SIGMA/SML2186 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 683808-78-8
Empirical Formula (Hill Notation): C20H15BrF3NO2
Molecular Weight: 438.24
Linear Formula: C20H15BrF3NO2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
SMILES string | OC(CCC1=CC=C(C2=CC=C(Br)C |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Poloppin is a cell penetrant and potent inhibitor of mitotic Polo-like kinases (PLKs) that binds to the Polo-box domain (PBD) and prevents PLKs interaction with pSer/pThr phosphopeptide substrates. Poloppin induces mitotic arrest and apoptosis in cancer cells expressing mutant KRAS in 2D and organoid cultures. It also sensitizes mutant KRAS-expressing cancer cells to Crizotinib. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |