Zotarolimus

SIGMA/SML2196 - ≥95% (HPLC)

Synonym: (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin; ABT-578

CAS Number: 221877-54-9
Empirical Formula (Hill Notation): C₅₂H₇₉N₅O₁₂
Molecular Weight: 966.21
MDL Number: MFCD09752954
Linear Formula: C₅₂H₇₉N₅O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2196-5MG	5 mg	$94.20 1/EA	Add To Favorites
45-SML2196-25MG	25 mg	$306.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white to beige
form	powder
SMILES string	C[C@H](CC[C@@H](C[C@H](OC)/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@H](OC)[C@@H](/C(C)=C/[C@@H](C)C1=O)O)=O)C)C)O2)[C@]2(O)C(C(N3CCCC[C@H]3C(O[C@H]([C@H](C)C[C@@H]4CC[C@H](N5N=NN=C5)[C@H](OC)C4)C1)=O)=O)=O
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Zotarolimus (ABT-578) is a semi-synthetic rapamycin analog with immunosuppressant and anti-proliferative activity. It binds to the FKBP12 binding protein, which subsequently binds to the mammalian target of rapamycin (mTOR) causing cell cycle arrest in the G1 phase. Zotarolimus was designed to be used for delivery from drug-eluting coronary stents to prevent restenosis.
Biochem/physiol Actions:	Zotarolimus is a second generation Drug Eluting Stent (DES).

WGK Germany

WGK 3

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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