Zotarolimus
SIGMA/SML2196 - ≥95% (HPLC)
Synonym: (42S)
CAS Number: 221877-54-9
Empirical Formula (Hill Notation): C52H79N5O12
Molecular Weight: 966.21
MDL Number: MFCD09752954
Linear Formula: C52H79N5O12
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
SMILES string | C[C@H](CC[C@@H](C[C@H](OC |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | Zotarolimus (ABT-578) is a semi-synthetic rapamycin analog with immunosuppressant and anti-proliferative activity. It binds to the FKBP12 binding protein, which subsequently binds to the mammalian target of rapamycin (mTOR) causing cell cycle arrest in the G1 phase. Zotarolimus was designed to be used for delivery from drug-eluting coronary stents to prevent restenosis. |
Biochem/physiol Actions: | Zotarolimus is a second generation Drug Eluting Stent (DES). |
WGK Germany | WGK 3 |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |