Takinib

SIGMA/SML2216 - ≥98% (HPLC)

Synonym: N1-(1-Propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide

CAS Number: 1111556-37-6
Empirical Formula (Hill Notation): C₁₈H₁₈N₄O₂
Molecular Weight: 322.36
Linear Formula: C₁₈H₁₈N₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML2216-5MG	5 mg	$102.00 1/EA		Add To Favorites
45-SML2216-25MG	25 mg	$411.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
SMILES string	CCCN1C2=CC=CC=C2N/C1=NC(C3=CC(C(N)=O)=CC=C3)=O
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

Application:	Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.
Biochem/physiol Actions:	Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer.
General description:	Takinib belongs to the aminobenzimidazole class of inhibitors.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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