Takinib
SIGMA/SML2216 - ≥98% (HPLC)
Synonym: N1-
CAS Number: 1111556-37-6
Empirical Formula (Hill Notation): C18H18N4O2
Molecular Weight: 322.36
Linear Formula: C18H18N4O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
SMILES string | CCCN1C2=CC=CC=C2N/C1=NC( |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Application: | Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells. |
Biochem/physiol Actions: | Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer. |
General description: | Takinib belongs to the aminobenzimidazole class of inhibitors. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |