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CU-CPT9a

SIGMA/SML2221 - ≥98% (HPLC)

Synonym: 2-Methyl-4-(7-methoxyl-4-quinolinyl)-phenol; Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl

CAS Number: 2165340-32-7
Empirical Formula (Hill Notation): C17H15NO2
Molecular Weight: 265.31
Linear Formula: C17H15NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2221-5MG 5 mg
 $105.00
1/EA		 Add To Favorites
45-SML2221-25MG 25 mg
 $424.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
SMILES string CC1=CC(C2=CC=NC3=CC(OC)=CC=C23)=CC=C1O
solubility DMSO: 2 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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