MS436
SIGMA/SML2224 - ≥98% (HPLC)
Synonym: (E)
CAS Number: 1395084-25-9
Empirical Formula (Hill Notation): C18H17N5O3S
Molecular Weight: 383.42
MDL Number: MFCD27992062
Linear Formula: C18H17N5O3S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | faint brown to dark red |
form | powder |
SMILES string | O=S(C(C=C1)=CC=C1/N=N/C2= |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | MS436 is a diazobenzene-based potent BRD4 inhibitor with selective affinity toward the first bromodomain (BrD) of BRD4 (BRD4 BrD1 Ki <85 nM vs. BRD4 BrD2 Ki = 340 nM; IC50 = 460 nM/BRD4 BrD1 vs. 1.29 μM/BRD4 BrD2, 4.95 μM/CBP BrD, 20.29 μM/PCAF BrD). MS436 is a useful tool for probing BRD4-dependent cellular functions, including NF-κB-mediated proinflammatory response in RAW264.7 murine macrophages (IC50 in μM = 4.9/3.8 against LPS-induced IL-6/NO production), human and murine embryonic stem cell (ESC) pluripotency maintenance (10 μM), telomere elongation in mTERT/mTR-overexpressing murine fibroblasts (5 μM), and bioenergetic deficiency caused by mitochondrial complex I (CI)-mutation in human cybrid cells (0.9 μM). |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |