Synonym: 2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide; Nampt-IN-1; 2-Hydoxy-2-methyl-N-{2-[(pyridin-3-yloxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-6-YL}propane-1-sulfonamide
CAS Number: 1698878-14-6
Empirical Formula (Hill Notation): C20H25N3O5S
Molecular Weight: 419.49
MDL Number: MFCD28963946
Linear Formula: C20H25N3O5S
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
LSN3154567 is an orally available, potent and highly selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). LSN3154567 exhibits broad spectrum and potent anticancer activities without causing retinopathy in the rat. LSN3154567co-administration with nicotinic acid (NA) produces potent anti-tumor activity in tumor xenograft models without retinal and hematological toxicities. |
| Biochem/physiol Actions: |
LSN3154567 might be useful in developing a novel cancer therapeutic. |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
