Synonym: Ramelteon solution; (S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide; N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide; TAK 375; TAK-375
CAS Number: 196597-26-9
Empirical Formula (Hill Notation): C16H21NO2
Molecular Weight: 259.34
MDL Number: MFCD08067736
Linear Formula: C16H21NO2
Product Type: Chemical
| color |
white to beige |
| form |
powder |
| InChI |
1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1 |
| InChI key |
YLXDSYKOBKBWJQ-LBPRGKRZSA-N |
| optical activity |
[α]/D -50 to -60°, c = 1.0 in chloroform-d |
| SMILES string |
CCC(NCC[C@H]1C(C(CCO2)=C2C=C3)=C3CC1)=O |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Ramelteon is a cell penetrant, potent and selective agonist at MT1/MT2 melatonin receptor that exhibits sleep-promoting properties. It is not binding to GABA receptor complex. Ramelteon is an analog of melatonin recently approved to treat insomnia. |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P301 + P312 + P330 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
