Everolimus
SIGMA/SML2282 - ≥95% (HPLC)
Synonym: Everolimus; 40-
CAS Number: 159351-69-6
Empirical Formula (Hill Notation): C53H83NO14
Molecular Weight: 958.22
MDL Number: MFCD00929329
Linear Formula: C53H83NO14
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C53H83NO14/c1-32-16-12 |
InChI key | HKVAMNSJSFKALM-GKUWKFKPSA |
shipped in | wet ice |
SMILES string | O=C(C([C@@]1(O)[C@H](C)CC |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Application: | Everolimus has been used as an mechanistic target of rapamycin complex 1 (mTORC1) inhibitor to study its effect on MCF7 and MDA-MB-231 cell lines. |
Biochem/physiol Actions: | Everolimus, a substrate for P-glycoprotein (P-gp) can be used to treat advanced neuroendocrine tumors (NETs). |
Biochem/physiol Actions: | Everolimus, the 40-O-(2-hydroxyethyl) derivative of rapamycin (sirolimus), is a potent and selective inhibitor of mechanistic target of rapamycin (mTOR). Everolimus is selective for the mTORC1 protein complex. Everolimus exhibit potent immunosuppressive and anticancer activities. |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H351 - H361fd - H373 - H410 |
Precautionary statements | P202 - P260 - P273 - P280 - P308 + P313 - P391 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |