Vildagliptin
SIGMA/SML2302 - ≥98% (HPLC)
Synonym: Vildagliptin; (2S)
CAS Number: 274901-16-5
Empirical Formula (Hill Notation): C17H25N3O2
Molecular Weight: 303.40
MDL Number: MFCD08275142
Linear Formula: C17H25N3O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C17H25N3O2/c18-9-14-2- |
InChI key | SYOKIDBDQMKNDQ-NHMCJKAESA |
optical activity | [α]/D -81 to -91°, c = 0.1 in methanol |
SMILES string | N#C[C@H]1N(CCC1)C(CN[C@@] |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Application: | Vildagliptin has been used: • as a dipeptidyl peptidase-4 (DPP4) inhibitor to study its effects on endoplasmic reticulum (ER) pathway under diabetic conditions • in pharmacological inhibition to investigate the kinetics of transposable element (TE) desilencing and confirm its dependence on DPF-3 (a P-granule-localized N-terminal dipeptidase) enzymatic activity • to study its electrochemical properties and determination in biological fluid and drug forms |
Biochem/physiol Actions: | Vildagliptin ia a selective inhibitor of dipeptidyl peptidase 4 (DPP4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones that are released in response to a meal. By preventing GLP-1 and GIP inactivation, GLP-1 and GIP are able to potentiate the secretion of insulin and suppress the release of glucagon by the pancreas. |
Biochem/physiol Actions: | Vildagliptin may participate in lipid metabolism. It plays a key role in attenuating postprandial hypertriglyceridemia, reducing serum triglycerides, apolipoprotein B, and blood total cholesterol levels. Vildagliptin is used in diabetes mellitus type 2 (DM2) therapy and may also possess vasculoprotective properties. Vildagliptin also helps to improve mitochondrial dysfunction caused by diabetes. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |