Synonym: 6-O-Butanoylcastanospermine; 6-O-Butyrylcastanospermine; BuCast; Butanoic acid (1S,6S,7S,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl ester; Butanoic acid [1S-(1α,6β,7α,8β,8aβ)]-octahydro-1,7,8-trihydroxy-6-indolizinyl ester; MDL 28,574; MDL 28574; MDL-28574
CAS Number: 121104-96-9
Empirical Formula (Hill Notation): C12H21NO5
Molecular Weight: 259.30
MDL Number: MFCD00886617
Linear Formula: C12H21NO5
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
InChI |
1S/C12H21NO5/c1-2-3-9(15)18-8-6-13-5-4-7(14)10(13)12(17)11(8)16/h7-8,10-12,14,16-17H,2-6H2,1H3/t7-,8-,10+,11+,12+/m0/s1 |
InChI key |
HTJGLYIJVSDQAE-VWNXEWBOSA-N |
SMILES string |
O[C@@H]1[C@@H](OC(CCC)=O)CN2[C@@]([C@@H](O)CC2)([H])[C@H]1O |
solubility |
H2O: 2 mg/mL, clear |
storage condition |
desiccated |
|
under inert gas |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Celgosivir is a prodrug of natural bicyclic iminosugar castanospermine that exhibits antiviral activity in vivo including HCV and dengue. Celgosivir is an inhibitor of α-glucosidases, which inhibits glycoprotein processing in cell culture. Apparently inhibition of α-glucosidases within infected cell prevents secretion of virus. |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |