Dynarrestin
SIGMA/SML2332 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 2222768-84-3
Empirical Formula (Hill Notation): C22H23F2N3O2S
Molecular Weight: 431.50
Linear Formula: C22H23F2N3O2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to brown |
form | powder |
SMILES string | CCN(CC)C1=CC=C(C2=C(C(OCC |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Dynarrestin is a potent and selective reversible inhibitor of cytoplasmic dyneins 1 and 2 that inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis. It inhibits endosome movement and disturbs mitosis in cells. Dynarrestin inhibits dynein 2-mediated intraflagellar transport of the cargo IFT88 and flux of Smo within cilia. Also it inhibits cancer cells proliferation downstream of Smo. |
Biochem/physiol Actions: | Dynarrestin is an aminothiazole derivative, which can bind to protein tyrosine phosphatase interacting protein 51 (PTPIP51). This interaction helps in regulating various signaling pathways that lead to proliferation and migration. Dynarrestin blocks hedgehog (Hh)-dependent signaling in mouse and human cells. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |