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Isavuconazole

SIGMA/SML2357 - ≥98% (HPLC)

Synonym: (2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; 1-[(2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazole; 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile; BAL 4815; RO 0094815

CAS Number: 241479-67-4
Empirical Formula (Hill Notation): C22H17F2N5OS
Molecular Weight: 437.47
MDL Number: MFCD06407745
Linear Formula: C22H17F2N5OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2357-5MG 5 mg
 $94.20
1/EA		 Add To Favorites
45-SML2357-25MG 25 mg
 $381.00
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assay ≥98% (HPLC)
color white to beige
form powder
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Application: Isavuconazole has been used as an antifungal agent to test its effect on Mucor circinelloides gene transcription. It has also been used
to analyze its in vitro activity against isolates from the R. argillacea species complex A. fumigatus, N. hiratsukae and C. parapsilosis.
Biochem/physiol Actions: Isavuconazole is a triazole antifungal drug. It inhibits fungal sterol biosynthesis by inhibition of cytochrome P450 sterol 14-α-demethylase (CYP51), an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. It has been approved for the treatment of both invasive aspergillosis and invasive mucormycosis.
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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