(Z)-Endoxifen
SIGMA/SML2368 - ≥98% (HPLC)
Synonym: 4-
Empirical Formula (Hill Notation): C25H27NO2
Molecular Weight: 373.49
MDL Number: MFCD09840374
Linear Formula: C25H27NO2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Application: | (Z)-Endoxifen has been used to demonstrate the lack of contribution of subventricular zone and leptomeningeal cells in a study determining the generation of neuroblasts from astrocytes. |
Biochem/physiol Actions: | (Z)-Endoxifen (endoxifen) is an active tamoxifen metabolite generated via actions of cytochrome P450 (CYP) enzymes CYP3A4/5 and CYP2D6. Endoxifen is more potent than tamoxifen as a selective estrogen receptor modulator (SERM) both in vitro and in vivo with good pharmacokinetics and oral availability (∼80% MCF-7 tumor growth inhibition with 4-8 mg/kg/day endoxifen or 20 mg/kg/day tamoxifen in mice via p.o.). Endoxifen also exhibits 4-fold higher PKC inhibitory potency than tamoxifen and can overcome tamoxifen resistance due to cytochrome CYP2D6 polymorphism. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H400 |
Precautionary statements | P273 - P391 - P501 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |