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FC-99 hydrochloride

SIGMA/SML2371 - ≥98% (HPLC)

Synonym: FC 99 hydrochloride; FC99 hydrochloride; N1-[(4-Methoxyphenyl)methyl]-4-methyl-1,2-benzenediamine hydrochloride

CAS Number: 1097810-71-3 (free base)
Empirical Formula (Hill Notation): C15H18N2O · xHCl
Molecular Weight: 242.32 (free base basis)
Linear Formula: C15H18N2O · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2371-5MG 5 mg
 $99.00
1/EA		 Add To Favorites
45-SML2371-25MG 25 mg
 $399.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
SMILES string CC1=CC(N)=C(C=C1)NCC2=CC=C(C=C2)OC
solubility H2O: 2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: FC-99 is a benzenediamine derivative that inhibits LPS-induced IRAK4 phosphorylation/activation and downstream signaling events (5-45 μM; murine RAW 264.7 & peritoneal macrophages), including IRAK1 (a TLR3 pathway negative regulator) degradation, p38/ERK/JNK activation, and cytokines production. FC-99 inhibits RSV replication (50 μM; A549) and poly(I:C)-indued IRF3/IFN-α/JAK/STAT1 signalling in cultures (0.5-50 μM; murine peritoneal macrophages), and ameliorates sepsis induction following caecal ligation puncture (CLP) in mice in vivo (100/70/32.5% motality in 7 days with 0/30/100 mg/kg i.p. 2 h prior to CLP).
Biochem/physiol Actions: FC-99 is known to affect the levels of serum immunoglobulin. It might be therapeutically beneficial in systemic lupus erythematosus.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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