Synonym: β-MCA; (3a,5b,6b,7b)-3,6,7-trihydroxy-cholan-24-oic acid; 5β-Cholanic acid-3α,6β,7β-triol; beta-Muricholic Acid
CAS Number: 2393-59-1
Empirical Formula (Hill Notation): C24H40O5
Molecular Weight: 408.57
MDL Number: MFCD00271403
Linear Formula: C24H40O5
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13?,14-,15?,16?,17?,18+,20?,21+,22-,23-,24-/m1/s1 |
| InChI key |
DKPMWHFRUGMUKF-CWNVCPLQSA-N |
| optical activity |
[α]/D +59 to +65°, c = 0.5 in methanol |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
−20°C |
| Application: |
β-Muricholic Acid has been used as a bile acid to study its effects on the expression of pluripotency, stemness, and inflammatory genes in primary mouse hepatocytes (PMH) and tumor-initiating stem-like cells(TICs). It has also been used as a bile acid to study its effects on gut transit ingnotobiotic or conventional mouse models. |
| Biochem/physiol Actions: |
β-Muricholic acid (β-MCA) is a natural murine-specific bile acid. β-Muricholic acid has been shown to reduce the absorption of cholesterol. It also has some activity as a farnesoid X receptor antagonist. |
| Biochem/physiol Actions: |
β-Muricholic Acid is a naturally occurring trihydroxy hydrophilic bile acid that is produced in the liver of murine. It serves as a biliary cholesterol-desaturating agent and aids in the dissolution of cholesterol gallstones. |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
