Synonym: (E)-4-(5-(Methoxycarbonyl)-2,2′-bithiophen-4-ylamino)-4-oxobut-2-enoic acid; 4-[(3-Carboxy-1-oxo-2-propenyl)amino]-[2,2′-bithiophene]-5-carboxylic acid 5-methyl ester; 4-{[2-(Methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid; HTS 01037; HTS-01037
CAS Number: 682741-29-3
Empirical Formula (Hill Notation): C14H11NO5S2
Molecular Weight: 337.37
MDL Number: MFCD02681826
Linear Formula: C14H11NO5S2
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
solubility |
DMSO: 2 mg/mL, clear |
storage temp. |
−20°C |
Biochem/physiol Actions: |
HTS01037 is a selective, high-affinity fatty acid-binding protein FABP4 (AFABP; aP2) antagonist (aP2 Ki = 0.67 μM; EFABP/HF/IFABP/LFABP Ki = 3.40/9.07/6.57/8.17 μM) that targets aP2 long-chain fatty acid-binding site. HTS01037 is shown to downregulate basal and fatty acid-stimulated LTC4 levels in primary murine peritoneal macrophages (0.2-20 μM), upregulate murine macrophage RAW 264.7 intracellular free fatty acids and uncoupling protein 2 (UCP2) mRNA levels (30 μM), as well as suppress PPARγ target genes expression in IL-4 polarized human primary macrophages (10-25 μM). |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |