Synonym: Isosilybin, mixture of isomers; (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; Isosilybinin; Isosilybinin
CAS Number: 72581-71-6
Empirical Formula (Hill Notation): C25H22O10
Molecular Weight: 482.44
MDL Number: MFCD09842608
Linear Formula: C25H22O10
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3 |
| InChI key |
FDQAOULAVFHKBX-UHFFFAOYSA-N |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Isosilybin is a diastereoisomeric mixture of flavonolignans isosilybin A and isosilybin B isolated from milk thistle (Silybum marianum) that exhibits hepatoprotective activity. Isosilybin potently inhibits Cytochrome P4502C8 (CYP2C8) activity in human liver microsomes. Also Isosilybin is an activator of PPARγ. |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
GHS07