Synonym: 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride
CAS Number: 152-53-4
Empirical Formula (Hill Notation): C11H14ClN5 · HCl
Molecular Weight: 288.18
MDL Number: MFCD00035308
Linear Formula: C11H14ClN5 · HCl
Product Type: Chemical
assay |
≥95% (HPLC) |
color |
white to beige |
form |
powder |
InChI |
1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H |
InChI key |
MOUAPRKJJUXEIE-UHFFFAOYSA-N |
solubility |
H2O: 2 mg/mL, clear |
storage condition |
desiccated |
storage temp. |
−20°C |
Application: |
Cycloguanil hydrochloride is suitable for use as a positive control in screening Plasmodium falciparum strains in microdilution radioisotope antiplasmodial bioassay. It may also be used as internal standard in high performance liquid chromatography for the quantification of urine and plasma samples. |
Biochem/physiol Actions: |
Cycloguanil is it a potential antimalarial drug. It is hydrophilic in nature. Cycloguanil acts as a substrate for the enzyme organic cation transporter 1 (OCT1). |
Biochem/physiol Actions: |
Cycloguanil, a metabolite of proguanil, is a potent dihydrofolate reductase inhibitor. |
Purity |
≥95% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |