AP39
SIGMA/SML2389 - ≥95% (HPLC)
Synonym: (10-
CAS Number: 1429061-80-2
Empirical Formula (Hill Notation): C37H38BrO2PS3
Molecular Weight: 721.77
Linear Formula: C37H38BrO2PS3
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to dark orange |
form | powder |
shipped in | wet ice |
SMILES string | O=C(OC1=CC=C(C2=CC(SS2)=S |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | AP39 is a anethole dithiolethione (ADT-OH)-derivatized hydrogen sulfide (H2S) donor with a lipophilic & positively charged triphenylphosphonium (TP) moiety for mitochondrially targeted H2S release. AP39 stimulates mitochondrial electron transport and cellular bioenergetic function, protecting against mitochondrial DNA damage and cell death upon oxidative stress induction (effective conc. 30–100 nM; bEnd.3 cells). AP39 in vivo efficacy (0.1-1 μmol/kg i.v.; 0.1-0.3 mg/kg i.p.) is demonstrated in varous rodent models, including neurological damage post cardiac arrest, renal injury post ischemia-reperfusion, burn-caused organ damage, as well as brain atrophy in APP/PS1 mice. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |