Synonym: 11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride; 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride; Compound 21 dihydrochloride
CAS Number: 56296-18-5 (free base)
Empirical Formula (Hill Notation): C17H18N4 · 2HCl
Molecular Weight: 351.27
MDL Number: MFCD25121806
Linear Formula: C17H18N4 · 2HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow to brown |
| form |
powder |
| SMILES string |
C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1 |
| solubility |
H2O: 2 mg/mL, clear |
| storage condition |
desiccated |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh). |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
GHS07