α-DHED
SIGMA/SML2396 - ≥98% (HPLC)
Synonym: 10ß,17a-
CAS Number: 2362514-18-7
Empirical Formula (Hill Notation): C18H24O3
Molecular Weight: 288.38
Linear Formula: C18H24O3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
SMILES string | O[C@@]12C(CC[C@]3([H])[C@ |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain with little production in the periphery. α-DHED has no estrogenic activity itself with little affinity for either ERα and ERβ estrogen receptors. 17α-estradiol (αE2) has been proposed to have potential roles in various neurodegenerative disorders including neuroprotection of the brain and the prevention/treatment of Alzheimer’s disease, but peripheral side-effects on estrogen-sensitive organs have been problematic. α-DHED, a prodrug without estrogenic activity, could help alleviate those concerns. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |