α-DHED

SIGMA/SML2396 - ≥98% (HPLC)

Synonym: 10ß,17a-Dihydroxyestra-1,4-dien-3-one; alpha-DHED

CAS Number: 2362514-18-7
Empirical Formula (Hill Notation): C₁₈H₂₄O₃
Molecular Weight: 288.38
Linear Formula: C₁₈H₂₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2396-5MG	5 mg	$111.00 1/EA	Add To Favorites
45-SML2396-25MG	25 mg	$443.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
SMILES string	O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@H]4O)=CC(C=C1)=O
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

α-DHED is a bioprecursor prodrug of 17α-estradiol ((Alfatradiol)) that results in 17α-estradiol being produced selectively in the brain with little production in the periphery. α-DHED has no estrogenic activity itself with little affinity for either ERα and ERβ estrogen receptors. 17α-estradiol (αE2) has been proposed to have potential roles in various neurodegenerative disorders including neuroprotection of the brain and the prevention/treatment of Alzheimer’s disease, but peripheral side-effects on estrogen-sensitive organs have been problematic. α-DHED, a prodrug without estrogenic activity, could help alleviate those concerns.

WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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