JI130
SIGMA/SML2406 - ≥95% (HPLC)
Synonym: (E)
CAS Number: 2234271-86-2
Empirical Formula (Hill Notation): C23H24N2O3
Molecular Weight: 376.45
Linear Formula: C23H24N2O3
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
SMILES string | O=C(/C=C/C1=CNC2=C1C=CC=C |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | JI130 is a cell penetrant, potent and selective inhibitor of the helix-loop-helix transcription factor Hes1 that blocks Hes1-mediated transcriptional repression. JI130 potently inhibits pancreatic cancer cell lines proliferation, and shrink tumor in a mice pancreatic tumor xenograft model. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |