UNC3866 trifluoroacetate salt
SIGMA/SML2408 - ≥98% (HPLC)
Synonym: N-
Empirical Formula (Hill Notation): C43H66N6O8
Molecular Weight: 795.02
Linear Formula: C43H66N6O8
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to off-white |
form | lyophilized powder (white) |
shipped in | wet ice |
storage temp. | −20°C |
Biochem/physiol Actions: | Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1 |
Biochem/physiol Actions: | UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |