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UNC3866 trifluoroacetate salt

SIGMA/SML2408 - ≥98% (HPLC)

Synonym: N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate

Empirical Formula (Hill Notation): C43H66N6O8
Molecular Weight: 795.02
Linear Formula: C43H66N6O8
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2408-5MG 5 mg
 $139.00
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45-SML2408-25MG 25 mg
 $559.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form lyophilized powder (white)
shipped in wet ice
storage temp. −20°C
Biochem/physiol Actions: Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1
Biochem/physiol Actions: UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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