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HET0016

SIGMA/SML2416 - ≥95% (HPLC)

Synonym: HET 0016; HET-0016; N′-(4-Butyl-2-methylphenyl)-N-hydroxymethanimidamide; N-(4-Butyl-2-methylphenyl)-N′-hydroxyformamidine; N-(4-Butyl-2-methylphenyl)-N′-hydroxymethanimidamide; N-Hydroxy-N′-(4-n-butyl-2-methylphenyl)formamidine

CAS Number: 339068-25-6
Empirical Formula (Hill Notation): C12H18N2O
Molecular Weight: 206.28
Linear Formula: C12H18N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2416-5MG 5 mg
 $70.40
1/EA		 Add To Favorites
45-SML2416-25MG 25 mg
 $286.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color white to beige
form powder
SMILES string CCCCC1=CC=C(C(C)=C1)/N=C/NO
solubility DMSO: 2 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: HET0016 is a potent and selective inhibitor against cytochrome P450 (CYP450) ω-hydroxylases (human CYP4A11/4A22/4F2/4F3, rat CYP4A1/4A2/4A3/4A8)-mediated 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis (IC50 = 8.9/35 nM using human/rat renal microsomes), exhibiting much reduced potency against epoxyeicosatrienoic acids (EETs) biosynthesis (IC50 = 2.8 μM/rat microsome) or the enzyme activities of CYP2C9/2D6/3A4 and COX (IC50 = 3.3/83.9/71 μM and 2.3 μM). HET0016 is widely employed both in cultures (1-10 μM) and in aminals in vivo (1-10 mg/kg via i.v., i.m., i.p. or s.c.) for probing 20-HETE-dependent physiological and pathological processes.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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