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GSK690

SIGMA/SML2419 - ≥98% (HPLC)

Synonym: (R)-4-(5-(Pyrrolidin-3-ylmethoxy)-2-(p-tolyl)pyridin-3-yl) benzonitrile); (R)-4-(5-(Pyrrolidin-3-ylmethoxy)-2-p-tolylpyridin-3-yl)benzonitrile; 4-(2-(4-Methylphenyl)-5-((3R)-3-pyrrolidinylmethoxy)-3-pyridinyl)benzonitrile; GSK 354; GSK 690; GSK-354; GSK-690; GSK354

CAS Number: 2101305-84-2
Empirical Formula (Hill Notation): C24H23N3O
Molecular Weight: 369.46
Linear Formula: C24H23N3O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2419-5MG 5 mg
 $79.00
1/EA		 Add To Favorites
45-SML2419-25MG 25 mg
 $319.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
SMILES string N#CC1=CC=C(C2=CC(OC[C@H]3CNCC3)=CN=C2C4=CC=C(C)C=C4)C=C1
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: GSK690 (GSK354) is a cell-permeable pyrrolidinylmethoxypyridine-based compound that inhibits lysine-specific demethylase 1 (LSD1; KDM1A) in a potent and reversible manner (IC50 = 90 nM) without affecting MAO-A activity (IC50 >200 μM). GSK690 is shown to induce the expressions of CD86 (EC50 = 1.4 μM in THP1 cells) and LY96 (EC50 = 423 nM in MV4-11 cells), and prevent adipogenesis in murine preadipocyte cultures.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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