Tandutinib hydrochloride
SIGMA/SML2672 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 387867-13-2 (free base)
Empirical Formula (Hill Notation): C31H42N6O4 · xHCl
Molecular Weight: 562.70 (free base basis)
Linear Formula: C31H42N6O4 · xHCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
solubility | H2O: 2 mg/mL, clear |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Tandutinib (CT53518, MLN518) is a potent receptor tyrosine kinase inhibitor against PDGFRβ, c-Kit, Flt3 (IC50 = 0.20, 0.17, 0.22, 3.43 μM, respectively, against 8 nM PDGF-BB induced autophosphorylation of βPDGFR, βPDGFR/c-Kit, βPDGFR/Flt3, βPDGFR/CSF-1R chimera expressed in CHO cells; IC50 =30 μM against KDR, EFGR, FGFR, InsR, Abl, Src, PKA, PKC, ERK2, MEK1, MKK4/6, p38). Tandutinib prolongs the survival in murine CMML (Baf3 with Tel/βPDGFR chimera) and Flt-3/ITD AML leukemia models (60 mg/kg bid p.o.) with good oral bioavailability. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |