Synonym: 1,1′-[[1,1′-Biphenyl]-4,4′-diylbis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium dibromide (9CI); 1,1′-[[[1,1′-Biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium] bromide; RSM 932A; TCD-717
CAS Number: 850807-63-5
Empirical Formula (Hill Notation): C46H38Cl2N4 · 2Br
Molecular Weight: 877.53
Linear Formula: C46H38Cl2N4 · 2Br
Product Type: Chemical
assay |
≥97% (HPLC) |
color |
faint yellow to dark orange |
form |
powder |
SMILES string |
CN(C1=CC=[N+](CC2=CC=C(C3=CC=C(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C6=CC=CC=C46)C=C3)C=C2)C7=CC=CC=C17)C8=CC=C(Cl)C=C8 |
solubility |
H2O: 2 mg/mL, clear |
storage condition |
desiccated |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
RSM932A is a potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells via prolonged activation of ER stress response and C/EBP homologous protein (CHOP) overproduction. RSM932A decreases de novo in phosphatidylcholine synthesis and increases ceramides levels that selectively trigger apoptosis in cancer cells. On the other hand, RSM932A induces reversible G0/G1 cell cycle arrest in nontumorigenic cells. RSM932A exhibits potent antiproliferative activity in array of human cancer cell lines. |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥97% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |