SHMT inhibitor Hit 1
SIGMA/SML2699 - ≥98% (HPLC)
Synonym: 4,4′-[2,4-Pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo-butanoic acid
CAS Number: 330638-43-2
Empirical Formula (Hill Notation): C24H22N4O6
Molecular Weight: 462.45
Linear Formula: C24H22N4O6
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C(NC1=CC=C(C2=NC=CC(C3= |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Inhibition of serine/glycine synthesis by SHMT inhibitors can be an effective strategy to treat serine/glycine synthesis-dependent cancers. Therefore, SHMT inhibitor can be a potential cancer drug target. SHMT inhibitor Hit 1 may inhibit SHMT with an IC50 of 0.53 μM. |
Biochem/physiol Actions: | SHMT inhibitor Hit 1 is a potent and specific inhibitor of serine hydroxymethyltransferase (SHMT). SHMT inhibitor Hit 1 potently inhibits SHMT1 and SHMT2 in rat liver homogenate. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |