BAY-293
SIGMA/SML2703 - ≥98% (HPLC)
Synonym: 6,7-
CAS Number: 2244904-70-7
Empirical Formula (Hill Notation): C25H28N4O2S
Molecular Weight: 448.58
Linear Formula: C25H28N4O2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| optical activity | [α]/D -85.0 to -103.0°, c = 1.0 in DMSO |
| Quality Level | 100  |
| SMILES string | C[C@H](C1=CC(C2=CC=CC=C2C |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | BAY-293 selectively inhibits SOS1-mediated KRAS activation (IC50 = 52 nM; 50 nM wt or G12C hKRAS & 10 nM SOS1cat) via direct SOS1 binding, blocking SOS1-KRAS interaction (IC50 = 21 nM; 10 nM hSOS1cat & 5 nM hKRAS G12C) without affecting (IC50 >20 μM) CRAF RBD-KRAS interaction, KRAS G12C activation by SOS2, Cdc42 activation by DBS, or EGFR kinase activity. BAY-293 downregulates cellular active RAS (IC50 = 200 nM/Calu-1, 410 nM/HeLa) and downstream ERK phosphorylation (K-562, 150 nM/Calu-1) with good target selectivity as assessed over 358 kinases (<37% inhibition at 1 μM) and a panel of 77 GPCRs, transporters, nuclear receptors and enzymes. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |