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BAY-294

SIGMA/SML2704 - ≥98% (HPLC)

Synonym: BAY-294; 6,7-Dimethoxy-2-methyl-N-[(S)-1-(4-{2-[(methylamino)methyl]phenyl}thien-2-yl)ethyl]quinazolin-4-amine; BAY 293 (S)-enantiomer; BAY 293 control; BAY 294; BAY-293 (S)-enantiomer; BAY-293 control; BAY293 (S)-enantiomer; BAY293 control; BAY294

CAS Number: 2244904-69-4
Empirical Formula (Hill Notation): C25H28N4O2S
Molecular Weight: 448.58
Linear Formula: C25H28N4O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2704-5MG 5 mg
 $114.00
1/EA		 Add To Favorites
45-SML2704-25MG 25 mg
 $457.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
optical activity [α]/D +86.0 to +106.0°, c = 1.0 in DMSO
Quality Level 100 
SMILES string C[C@@H](C1=CC(C2=CC=CC=C2CNC)=CS1)NC3=C4C=C(C(OC)=CC4=NC(C)=N3)OC
solubility DMSO: 2 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: BAY-294 corresponds to the (S)-enantiomer of and the recommended control for the selective SOS1-KRAS interaction inhibitor BAY-293 (IC50 = 2.34 μM/BAY-294 vs. 21 nM/BAY-293; 10 nM hSOS1cat & 5 nM hKRAS G12C). BAY-294 exhibits little potency against SOS1-mediated KRAS activation (IC50 = 3.91 μM/BAY-294 vs. 52 nM/BAY-293; 10 nM SOS1cat & 50 nM wt hKRAS).
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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