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GSK2795039

SIGMA/SML2770 - ≥98% (HPLC)

Synonym: GSK 2795039; GSK-2795039; N-(1-Isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

CAS Number: 1415925-18-6
Empirical Formula (Hill Notation): C23H26N6O2S
Molecular Weight: 450.56
MDL Number: MFCD30489720
Linear Formula: C23H26N6O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2770-1MG 1 mg
 $94.20
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45-SML2770-5MG 5 mg
 $381.00
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assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string O=S(NC1=C2C(N(C(C)C)C=C2C3=CC4=C(C=C3)CCN4C)=NC=C1)(C5=NN(C)C=C5)=O
solubility DMSO: 2 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: GSK2795039 is a non-cytotoxic (100 μM, 24 hrs, HEK293), NADPH-competitive, potent and selective NOX2 inhibitor (IC50/[NADPH] = 447 nM/25 μM, 2.29 μM/1 mM by NADPH depletion measurement; eNOS & NOX1/3/4/5 IC50 >100 μM, PKCB II IC50 >25 μM, xanthine oxidase IC50 = 28.8 μM). GSK2795039 inhibits PMA-induced reactive oxygen species (ROS) production in cultures (IC50 = 182 nM; HL60) and exhibits in vivo efficacy against complete Freund′s adjuvant-induced paw inflammation (ED50 = 2 mg/kg, ED100 = 100 mg/kg ip.) as well as cerulein-induced acute pancreatitis (ED50 = 100 mg/kg ip.) in mice.
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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