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KDOAM25 hydrochloride hydrate

SIGMA/SML2774 - ≥98% (HPLC)

Synonym: 2-[[[2-[2-(Dimethylamino)ethyl-ethyl-amino]-2-oxidanylidene-ethyl]amino]methyl]pyridine-4-carboxamide hydrochloride hydrate; 2-[[[2-[2-(Dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridine-4-carboxamide hydrochloride hydrate; KDOAM-25 hydrochloride hydrate

Empirical Formula (Hill Notation): C15H25N5O2 · xHCl · yH2O
Molecular Weight: 307.39 (anhydrous free base basis)
MDL Number: MFCD30146416
Linear Formula: C15H25N5O2 · xHCl · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2774-5MG 5 mg
 $130.00
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45-SML2774-25MG 25 mg
 $503.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
solubility H2O: 2 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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