KDOAM25 hydrochloride hydrate
SIGMA/SML2774 - ≥98% (HPLC)
Synonym: 2-
Empirical Formula (Hill Notation): C15H25N5O2 · xHCl · yH2O
Molecular Weight: 307.39 (anhydrous free base basis)
MDL Number: MFCD30146416
Linear Formula: C15H25N5O2 · xHCl · yH2O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
solubility | H2O: 2 mg/mL, clear |
storage condition | desiccated |
storage temp. | −20°C |
Biochem/physiol Actions: | KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |