Nintedanib
SIGMA/SML2848 - ≥98% (HPLC)
Synonym: (3Z)
CAS Number: 656247-17-5
Empirical Formula (Hill Notation): C31H33N5O4
Molecular Weight: 539.62
MDL Number: MFCD11974012
Linear Formula: C31H33N5O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C(NC1=C2)/C(C1=CC=C2C(O |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC50 = 34/21/13 nM), FGFR-1/2/3/4 (IC50 = 69/37/108/610 nM), PDGFRα/β (IC50 = 59/65 nM), as well as Flt-3, Lck, Lyn, and Src (IC50 = 26, 16, 195, 156 nM, repectively), but not 33 other kinases. Nintedanib exhibits antiangiogenic and antifibrotic efficacy in cultures and in animal models of cancers and pulmonary fibrosis in vivo. |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H301 - H315 - H318 - H361fd - H372 |
Precautionary statements | P201 - P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |